Description
Product Characteristics:
The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. ArgRS (Arginyl-tRNA synthetase), also known as RARS or DALRD1, belongs to the class-I aminoacyl-tRNA synthetase family that includes the related proteins, LeuRS, ValRS and IleRS. These proteins are large monomeric proteins and play a major role in catalyzing the aminoacylation of tRNA by their cognate amino acid. ArgRS localizes to the cytoplasm and exists as a monomer but can also associate with other tRNA synthetases and auxiliary proteins to form a multisubunit complex. In the presence of ATP, arginine (Arg) and tRNA, ArgRS joins Arg to tRNA(Arg) at its synthetic active site. Two cytoplasmic forms of ArgRS have been described in mammals, differing by the addition of a 73 amino acid sequence that is required for ArgRS assembly into the multisubunit complex.
Subcellular location: Cytoplasm
Synonyms: There are 2 isoforms produced by alternative initiation.Alternative names2610011N19Rik, 2610037E21Rik, AL033339, Arginine tRNA ligase 1, cytoplasmic, Arginine tRNA ligase, Arginine--tRNA ligase, Arginyl tRNA synthetase 1, Arginyl tRNA synthetase cytoplasmic, Arginyl tRNA synthetase, cytoplasmic, Arginyl-tRNA synthetase, cytoplasmic, ArgRS, AW985894, DALRD 1, DALRD1, EC 6.1.1.19, MGC8641, MGC86730, RARS, SYRC_HUMAN, wu:fa96g09, zgc:56050, zgc:86730.
Target Information: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]